Villa Mondragone is a patrician villa on a hill 416 meters above sea level, about 20 kilometers southeast of Rome, near the ancient town of Tusculum. It was originally in Frascati and is now in Monte Porzio Catone, in the Alban Hills. Construction began in 1573 for Cardinal Mark Sittich von Hohenems Altemps, and Martino Longhi the Elder designed it. The site held remains of a Roman villa of the Quinctilii family.
Pope Gregory XIII used it as a summer residence. In 1582 he issued the bull Inter gravissimas there, which began the Gregorian calendar. The Borghese family owned it at its greatest splendor and displayed art and antiquities there.
The Jesuits ran the Nobile Collegio Mondragone there from 1865 to 1953 and sold the villa to the university in 1981. It remains a seat of the University of Rome Tor Vergata.

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