San Simeone Profeta, also called San Simeone Grande, stands in the Santa Croce district of Venice, near Palazzo Gradenigo and Palazzo Soranzo Cappello. The patrician families Ghisi, Adoldi and Briosi founded it, and it existed by 967. A fire in 1150 led to a rebuilding in stone, and it became a parish church. Domenico Margutti rebuilt the interior in the early eighteenth century.
The facade is plain and Neoclassical. Burials during the plague of 1630 appear to have raised the interior floor. The Napoleonic government merged its parish with San Simeone Piccolo.
Jacopo Palma the Younger painted a Presentation at the Temple with donor portraits, to the right of the entrance. Tintoretto painted a Last Supper at the second altar of the left nave.
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