The Musée de Picardie is the main museum of Amiens and Picardy, at 48 rue de la République in Amiens, France. It was founded in 1802 as the Musée Napoléon, but its present building was purpose-built as a regional museum between 1855 and 1867. The architects Henri Parent and Arthur-Stanislas Diet designed it in the Second Empire style.
The Société des Antiquaires de Picardie made its construction possible, to house the collections it had gathered over decades. It was France's first building constructed exclusively to conserve and exhibit works of art, and it served as a prototype for other regional museums.
Puvis de Chavannes painted frescoes on the main staircase and in the first-floor galleries. The collections run from prehistory to the 19th century.

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